Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane

@article{Dong2021PolarizationsensitiveSR,
  title={Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane},
  author={Pu-Ting Dong and Cheng Zong and Z. Dagher and Jie Hui and Junjie Li and Yuewei Zhan and Meng Zhang and M. Mansour and Ji-Xin Cheng},
  journal={Science Advances},
  year={2021},
  volume={7}
}
Label-free stimulated Raman scattering microscopy resolves amphotericin B orientation in fungal cell membrane. Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening fungal infections. Two models have been proposed to illustrate AmB assembly in the cell membrane; one is the classical ion channel model in which AmB vertically forms transmembrane tunnel and the other is a recently proposed sterol sponge model where AmB is laterally adsorbed onto the membrane… Expand

References

SHOWING 1-10 OF 66 REFERENCES
The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model.
  • 5
Amphotericin B-Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly.
  • 1
Two-step impact of Amphotericin B (AmB) on lipid membranes: ESR experiment and computer simulations
  • 12
Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels.
  • 132
  • PDF
Raman spectroscopic study of aggregation process of antibiotic amphotericin B induced by H+, Na+, and K+ ions.
  • 17
Amphotericin primarily kills yeast by simply binding ergosterol
  • 351
  • PDF
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