Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis.

@article{Soki2014PolarizationOP,
  title={Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis.},
  author={Fabiana Naomi Soki and Amy Koh and Jacqueline D. Jones and Yeo Won Kim and Jinlu Dai and Evan Keller and Kenneth J. Pienta and Kamran Atabai and Hernan Roca and L. McCauley},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 35},
  pages={24560-72}
}
Tumor cells secrete factors that modulate macrophage activation and polarization into M2 type tumor-associated macrophages, which promote tumor growth, progression, and metastasis. The mechanisms that mediate this polarization are not clear. Macrophages are phagocytic cells that participate in the clearance of apoptotic cells, a process known as efferocytosis. Milk fat globule- EGF factor 8 (MFG-E8) is a bridge protein that facilitates efferocytosis and is associated with suppression of… CONTINUE READING
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