Polarization of human monocyte-derived dendritic cells to DC1 by in vitro stimulation with Newcastle Disease Virus.

@article{Fournier2009PolarizationOH,
  title={Polarization of human monocyte-derived dendritic cells to DC1 by in vitro stimulation with Newcastle Disease Virus.},
  author={Philippe Fournier and A. D. Arnold and Volker Schirrmacher},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  year={2009},
  volume={14 Suppl 1},
  pages={
          S111-22
        }
}
PURPOSE Dendritic cell (DC)-based tumor vaccines have been tested extensively to treat cancer patients. However, the results of several DC-based clinical trials have been disappointing. Amelioration of such a modality for cancer treatment seems warranted, i.e. by improving DC immunogenicity and polarization. The goal of our study was to evaluate the potential for immune activation of human DCs by incubating them in vitro with the Newcastle Disease Virus (NDV), a paramyxovirus with strong… CONTINUE READING

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