Polarization of host immune responses by helminth‐expressed glycans

@article{Tundup2012PolarizationOH,
  title={Polarization of host immune responses by helminth‐expressed glycans},
  author={Smanla Tundup and L. Srivastava and Jr. Donald A. Harn},
  journal={Annals of the New York Academy of Sciences},
  year={2012},
  volume={1253}
}
Helminth parasites bias host CD4+ T helper (Th) cells toward Th2 responses, drive alternative activation of macrophages, and expand T regulatory cells. Helminth‐expressed carbohydrates play critical roles in driving much of this immune cell biasing. Studies on helminth glycans have focused on Lewis X, LDN, LDN‐DF, other fucosylated structures, chitin, tyvelose, and trehalose, which interact with host antigen presenting cells (APCs) minimally via C‐type lectins and/or Toll‐like receptors (TLR… Expand
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  • T. Nutman
  • Biology, Medicine
  • Parasite immunology
  • 2015
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