Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis

  title={Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis},
  author={M Aurora Nieto and Jos{\'e} M. R. Frade and David de Sancho and Mario Mellado and Carlos Mart{\'i}nez-A and Francisco S{\'a}nchez-Madrid},
  journal={The Journal of Experimental Medicine},
  pages={153 - 158}
Leukocyte migration in response to cell attractant gradients or chemotaxis is a key phenomenon both in cell movement and in the inflammatory response. Chemokines are quite likely to be the key molecules directing migration of leukocytes that involve cell polarization with generation of specialized cell compartments. The precise mechanism of leukocyte chemoattraction is not known, however. In this study, we demonstrate that the CC chemokine receptors CCR2 and CCR5, but not cytokine receptors… CONTINUE READING
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