Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells.

@article{Morris1994PolarizationdependentAM,
  title={Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells.},
  author={Andrew P. Morris and Sonia A Cunningham and Albert Tousson and Dale J. Benos and Raymond A Frizzell},
  journal={The American journal of physiology},
  year={1994},
  volume={266 1 Pt 1},
  pages={C254-68}
}
The relationship between adenosine 3',5'-cyclic monophosphate (cAMP)-mediated Cl- secretion and the cellular location of the cystic fibrosis transmembrane conductance regulator (CFTR) was determined in both polarized (Cl.19A) and unpolarized (parental) HT-29 colonocytes expressing similar levels of CFTR mRNA and protein. CFTR immunolocalized to the apical membrane domain of polarized colonocytes exhibiting cAMP-responsive Cl- secretion. In contrast, CFTR staining was perinuclear in unpolarized… CONTINUE READING

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