Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries.

@article{Betz1978PolarityOT,
  title={Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries.},
  author={Anthony Betz and Gary W. Goldstein},
  journal={Science},
  year={1978},
  volume={202 4364},
  pages={225-7}
}
Capillary endothelial cells isolated from rat brain exhibit Na+-dependent uptake of the neutral amino acid analog alpha-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na+-dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the antiluminal plasma membrane appear to be functionally distinct. This polarity should permit brain… CONTINUE READING