Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility.

@article{Woods2019PolarityEB,
  title={Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility.},
  author={Benjamin K.S. Woods and Daniel J. Lew},
  journal={Small GTPases},
  year={2019},
  volume={10 2},
  pages={
          130-137
        }
}
Cell polarity is fundamental to the function of most cells. The evolutionarily conserved molecular machinery that controls cell polarity is centered on a family of GTPases related to Cdc42. Cdc42 becomes activated and concentrated at polarity sites, but studies in yeast model systems led to controversy on the mechanisms of polarization. Here we review recent studies that have clarified how Cdc42 becomes polarized in yeast. On one hand, findings that appeared to support a key role for the actin… CONTINUE READING
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