Polarisation of prokaryotic chromosomes.

@article{Lobry2003PolarisationOP,
  title={Polarisation of prokaryotic chromosomes.},
  author={J. R. Lobry and J Louarn},
  journal={Current opinion in microbiology},
  year={2003},
  volume={6 2},
  pages={101-8}
}
In many prokaryotes, asymmetrical mutational or selective pressures have caused compositional skews between complementary strands of replication arms, especially sensitive in the distribution of guanine and cytosine. In Escherichia coli, most of the guanine/cytosine skew is caused by mutation rates differing on leading and lagging strands, but contribution of skewed functionally important guanine-rich motifs (Chi and Rag sites), which control chromosome repair or positioning, is noticeable… CONTINUE READING

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