Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium.

@article{Birukova2007PolarHG,
  title={Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium.},
  author={Anna A Birukova and Panfeng Fu and Santipongse Chatchavalvanich and Dylan Burdette and Olga V. Oskolkova and Valery N. Bochkov and Konstantin G Birukov},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 4},
  pages={L924-35}
}
We have previously described protective effects of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) on pulmonary endothelial cell (EC) barrier function and demonstrated the critical role of cyclopentenone-containing modifications of arachidonoyl moiety in OxPAPC protective effects. In this study we used oxidized phosphocholine (OxPAPC), phosphoserine (OxPAPS), and glycerophosphate (OxPAPA) to investigate the role of polar head groups in EC barrier-protective responses to… CONTINUE READING