Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle

@article{Martin2009PolarGO,
  title={Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle},
  author={Sophie G. Martin and Martine Berthelot-Grosjean},
  journal={Nature},
  year={2009},
  volume={459},
  pages={852-856}
}
Cells normally grow to a certain size before they enter mitosis and divide. Entry into mitosis depends on the activity of Cdk1, which is inhibited by the Wee1 kinase and activated by the Cdc25 phosphatase. However, how cells sense their size for mitotic commitment remains unknown. Here we show that an intracellular gradient of the dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) Pom1, which emanates from the ends of rod-shaped Schizosaccharomyces pombe cells, serves to measure… Expand
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TLDR
This study demonstrates that Pom1 acts in a linear pathway to control cell cycle progression while regulating a complex network of cell growth targets and phosphorylated multiple substrates that function in polarized cell growth. Expand
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TLDR
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