Polar body cytokinesis

@article{Maddox2012PolarBC,
  title={Polar body cytokinesis},
  author={Amy Shaub Maddox and Jessica Azoury and Julien Dumont},
  journal={Cytoskeleton},
  year={2012},
  volume={69}
}
Polar body cytokinesis is the physical separation of a small polar body from a larger oocyte or ovum. This maternal meiotic division shares many similarities with mitotic and spermatogenic cytokinesis, but there are several distinctions, which will be discussed in this review. We synthesize results from many different model species, including those popular for their genetics and several that are more obscure in modern cell biology. The site of polar body division is determined before anaphase… Expand
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TLDR
Location of anillin as a conserved cytokinetic ring marker illustrates that the geometry of the cytokinetics ring is distinct between the two oogenic meiotic cytokineses in mammals. Expand
C. elegans CLASP/CLS-2 negatively regulates membrane ingression throughout the oocyte cortex and is required for polar body extrusion
TLDR
It is suggested that proper regulation by CLS-2 of both oocyte cortical stiffness and central spindle protein dynamics may influence contractile ring assembly during polar body extrusion in C. elegans oocytes. Expand
C. elegans CLASP/CLS-2 negatively regulates membrane ingression throughout the oocyte cortex and is required for polar body extrusion
TLDR
It is shown that spindle bipolarity and chromosome segregation are not required for polar body contractile ring formation and chromosome extrusion in klp-18 mutants, but oocytes with severe spindle assembly defects due to loss of CLS-2 or MEI-1 have penetrant and distinct polar body extrusion defects. Expand
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TLDR
It is suggested that Rac- and Arp2/3 mediated actin networks may directly antagonize Rho signaling, thus providing a potential mechanism to explain why Arp 2/3-nucleated branched actin Networks must be suppressed at the cell equator for successful cytokinesis. Expand
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TLDR
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Role of PB1 Midbody Remnant Creating Tethered Polar Bodies during Meiosis II
TLDR
The literature indicates that PB1 is tethered to the egg surface via PB2 in several species including members of the cnidarians, lophotrochozoa and echinoids, suggesting that the midbody remnant formed during PB1 emission may be involved in directing the precise site of PB2 emission throughout the invertebrates. Expand
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TLDR
What is known about the function of Rho family GTPases during cell division, as well as their upstream regulators and known downstream cytokinetic effectors are reviewed. Expand
Assembly and Positioning of the Oocyte Meiotic Spindle.
TLDR
This review highlights recent work that has shed light on the cytoskeletal structures that drive the meiotic divisions of the oocyte in mammals and focuses on how mammalian oocytes assemble a microtubule spindle in the absence of centrosomes, how they position theSpindle in preparation for polar body extrusion, and how the spindle segregates the chromosomes. Expand
Contributions of the actin cytoskeleton to the emergence of polarity during maturation in human oocytes.
TLDR
High-resolution confocal microscopy data indicate that, during maturation, cortical actin acquires a polarized distribution involving an accumulation in the domain adjacent the spindle and propose new questions concerning the existence of cytoplasmic actin in mature oocytes. Expand
The Process of First Polar Body Formation in Eggs of the Androgenetic Clam Corbicula fluminea
TLDR
The present study suggests that centrosomes at the first meiosis could have the equal ability to approach and attach to the membrane and induce polar body formation. Expand
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