Polar body analysis by array comparative genomic hybridization accurately predicts aneuploidies of maternal meiotic origin in cleavage stage embryos of women of advanced maternal age.

@article{Christopikou2013PolarBA,
  title={Polar body analysis by array comparative genomic hybridization accurately predicts aneuploidies of maternal meiotic origin in cleavage stage embryos of women of advanced maternal age.},
  author={Dimitra Christopikou and Erika Tsorva and Konstantinos A. Economou and Piran Shelley and Stephen Davies and Minas Mastrominas and Alan H. Handyside},
  journal={Human reproduction},
  year={2013},
  volume={28 5},
  pages={1426-34}
}
STUDY QUESTION How accurate is array comparative genomic hybridization (array CGH) analysis of the first polar body (PB1) and second polar body (PB2) in predicting aneuploidies of maternal meiotic origin in the cleavage stage embryos of women of advanced maternal age? SUMMARY ANSWER Almost all of the aneuploidies detected in cleavage stage embryos were associated with copy number changes in the polar bodies (93%) and all but one (98.5%) were predicted to be aneuploid. A minority of copy… CONTINUE READING

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Assessment of 19,803 paired chromosomes and clinical outcome from first 150 cycles using array CGH of the first polar body for embryo selection and transfer

  • S Fishel, A Craig, +7 authors A Campbell
  • J Fertil In Vitro
  • 2011
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