Poisoning with tilidine and naloxone: toxicokinetic and clinical observations.

@article{Regenthal1998PoisoningWT,
  title={Poisoning with tilidine and naloxone: toxicokinetic and clinical observations.},
  author={Ralf Regenthal and Martin Krueger and Manfred Richter and R. J. Preiss},
  journal={Human & experimental toxicology},
  year={1998},
  volume={17 11},
  pages={593-7}
}
The opioid analgesic tilidine and its metabolites were detected by high performance liquid chromatography (HPLC) with UV-detection in serum from a 28 year-old woman who ingested 100 ml Valoron (o)N containing 6.94 g of tilidine and about 0.56 g of naloxone with suicidal intention. Data on the toxicokinetics of tilidine in severe poisonings are missing. Therefore we followed serum concentrations of tilidine and metabolites for 48 or 96 h and for the first time calculated basic kinetic parameters… CONTINUE READING