Poisoning with the recreational drug paramethoxyamphetamine (“death”)

  title={Poisoning with the recreational drug paramethoxyamphetamine (“death”)},
  author={Liang Han Ling and Colin Marchant and Nicholas Alan Buckley and Michael Prior and Rod J Irvine},
  journal={Medical Journal of Australia},
To describe the clinical features of paramethoxyamphetamine (PMA; “death”) poisoning and to compare these with those of people with self‐reported “ecstasy” poisoning. 
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The clinician needs to be aware of the variety of pharmacologically active substances available in the recreational marketplace in order to diagnose and manage teenagers presenting to hospital with toxidromes.
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All fatalities attributed to PMMA had high PMMA blood concentrations compared to non-fatal cases, and a public warning is warranted against use and overdose with illegal ‘‘ecstasy’’ or “‘speed”’ drugs.
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Severe paramethoxymethamphetamine (PMMA) and paramethoxyamphetamine (PMA) outbreak in Israel
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  • Medicine
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A new street-drug, para-methoxyamphetamine (PMA), recently made its appearance in Ontario and appears to have a powerful hallucinogenic effect as well as a marked toxicity to the central nervous system.
Recent paramethoxyamphetamine deaths.
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As the popularity of MDMA has increased, so have reports of adverse nonpsychiatric and psychiatric consequences associated with use of the drug, and it is possible that some individuals with no apparent abnormalities might develop complications over time.
Amphetamine derivative fatalities in South Australia--is "Ecstasy" the culprit?
The number of deaths due to amphetamine derivatives apparently due to substitution of PMA for MDMA (Ecstasy) have recently increased markedly in Adelaide, and potential users are warned that PMA has a much higher rate of lethal complications than other designer drugs, and that no guarantee can be made that tablets sold as Ecstasy are not PMA.
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The history, neurochemistry, and toxicology of MDMA, as well as providing some guidance regarding management of toxic ingestion, can arm the provider with valuable information for use in the acute setting and assist providers in counseling young adults regarding the possible consequences of using this substance.
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Improved recognition of MDMA-related syndromes is hoped to provide insight into the function of serotonin in the human brain, in health as well as disease.
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The 'rave' movement, which spawned the widespread use of ecstasy, is now 10 years old and its history and the medical problems that have resulted are reviewed.
Amphetamine, not MDMA, is associated with intracranial hemorrhage.
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‘Designer Drugs’
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