Poisoning due to Pyrethroids

@article{Bradberry2005PoisoningDT,
  title={Poisoning due to Pyrethroids},
  author={Sally M. Bradberry and S. Cage and Alex T Proudfoot and J Allister Vale},
  journal={Toxicological Reviews},
  year={2005},
  volume={24},
  pages={93-106}
}
The first pyrethroid pesticide, allethrin, was identified in 1949. Allethrin and other pyrethroids with a basic cyclopropane carboxylic ester structure are type I pyrethroids. The insecticidal activity of these synthetic pyrethroids was enhanced further by the addition of a cyano group to give α-cyano (type II) pyrethroids, such as cypermethrin. The finding of insecticidal activity in a group of phenylacetic 3-phenoxybenzyl esters, which lacked the cyclopropane ring but contained the α-cyano… Expand
Introduction to Pyrethroid Insecticides: Chemical Structures, Properties, Mode of Action and Use
During the 1920s, pyrethrin was studied because of its potential as a precursor for synthetic organic pesticides. The first pyrethroid pesticide, allethrin, was identified in 1949. It is a type IExpand
The neurotoxicity of organochlorine and pyrethroid pesticides.
  • L. Costa
  • Biology, Medicine
  • Handbook of clinical neurology
  • 2015
TLDR
Evidence of an association between exposure to organochlorine and pyrethroid insecticides and neurodegenerative diseases (e.g., Parkinson's disease) is weak, at best. Expand
Current Research on the Safety of Pyrethroids Used as Insecticides
TLDR
The aim of the review is to provide comprehensive information on potential hazards associated to human exposure to deltamethrin, permethrin and alpha-cypermethrin. Expand
In Vitro Investigation on the Toxic Potentials of Commonly Used Synthetic Pyrethroids, Especially Esbiothrin
Abstract Pyrethroids, including allethrin, bioallethrin, deltamethrin, and esbiothrin, are widely used to control a broad range of pests in agriculture, public health, and households as alternativeExpand
Toxicology and Mode of Action of Pyrethroid Insecticides
TLDR
This chapter provides a review of the toxicological properties of pyrethroid insecticides in mammals, with emphasis on the neurotoxic properties that are characteristic of pyrethroids as a class. Expand
Poisoning due to Pyrethrins
TLDR
The pyrethrins are generally of low acute toxicity but convulsions may occur if substantial amounts are ingested and management of pyrethrin toxicity is supportive and symptomatic. Expand
Neurotoxicology of pyrethroid insecticides
Abstract Pyrethroid insecticides are neurotoxic to both insects and mammals. Most pyrethroids exhibit low to moderate acute oral toxicity to mammals, but the intrinsic toxicity of pyrethroids, whichExpand
Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos.
TLDR
Investigation of the developmental toxicity of six common pyrethroids and zebrafish embryos suggested that zebra fish may be an appropriate alternative model to study the mechanism(s) responsible for the developmental neurotoxicity of pyrethroid insecticides and aid in identification of compounds that should be further tested in mammalian systems. Expand
Use and abuse of pyrethrins and synthetic pyrethroids in veterinary medicine.
TLDR
Specific cases of pyrethroid poisoning in laboratory animals, fish, companion and large animals are considered, including the high incidence of feline pyrethroids toxicosis following the extra-label use of topical formulations. Expand
Binary combinations of organophosphorus and synthetic pyrethroids are more potent acetylcholinesterase inhibitors than organophosphorus and carbamate mixtures: An in vitro assessment.
Anticholinesterase insecticides such as organophosphorous (OP) and carbamates pesticides (CB); and synthetic pyrethroids (SP) pesticides commonly co-occur in the environment. This raises theExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 122 REFERENCES
Neurotoxicology of pyrethrin and the pyrethroid insecticides.
TLDR
A presumptive diagnosis of pyrethrin/pyrethroid poisoning is based upon history of exposure, development of appropriate clinical signs, and chemical analysis for insecticide residues. Expand
Degradation, metabolism and toxicity of synthetic pyrethroids.
  • J. Miyamoto
  • Biology, Medicine
  • Environmental health perspectives
  • 1976
TLDR
Based on existing toxicological information, the present recommended use patterns might afford sufficient safety margin on human population, however, in extending usage to agricultural pest control, much more extensive investigations should be forthcoming from both chemical and biological aspects, since there is scant information on the fate of these pyrethroids in the environment. Expand
Synthetic pyrethroid insecticides: a dermatological evaluation.
TLDR
Differences in cutaneous sensation were detected by human participants between synthetic pyrethroids with a cyano group in the (S)-configuration of the 3-phenoxybenzyl alcohol of their molecular structure (fenvalerate) and those that do not (permethrin). Expand
Sensitization risk of pyrethroid insecticides
  • P. Lisi
  • Chemistry, Medicine
  • Contact dermatitis
  • 1992
TLDR
The aim of the present study was to establish the irritation and sensitization risks of the most widely used pyrethroids. Expand
Biological monitoring of pyrethroid metabolites in urine of pest control operators.
TLDR
It was demonstrated that pyrethroid metabolites were detectable in urine for a period of elimination up to 3.5 days after exposure to cyfluthrin, and Fluorophenoxybenzoic acid was shown to be a suitable biomarker for exposure to CyFLuthrin. Expand
Pyrethroid Insecticides: Poisoning Syndromes, Synergies, and Therapy
TLDR
Pentobarbitone, however, is surprisingly effective as therapy against systemic type II pyrethroid poisoning in rats, probably due to its dual action as a chloride channel agonist and a membrane stabilizer. Expand
An assessment of the toxicological properties of pyrethroids and their neurotoxicity.
TLDR
Pyrethroids have been shown to cause functional changes (behavioral) in rats shown as a deficit in performance on an inclined plane and to cause morphological changes in peripheral nerves of rats when given in high doses. Expand
Pyrethroids, nerve poisons: how their risks to human health should be assessed.
TLDR
Overall, sound scientific bases exist for human risk assessment under the present usage conditions for pyrethroids including their preferentially manufactured stereoisomers. Expand
Comparison of therapeutic agents for synthetic pyrethroid exposure
TLDR
A new assay method, developed in this laboratory, has proven to be extremely sensitive in the detection of this dermal sensation of cutaneous dysesthesia among individuals occupationally exposed to synthetic pyrethroids. Expand
CHAPTER 58 – Pyrethroid Chemistry and Metabolism
This chapter starts by metabolism of pyrethroid insecticides in laboratory, focused mainly on in vivo metabolism. There are some species differences in in vitro microsome oxidation sites of allethrinExpand
...
1
2
3
4
5
...