Poisoning due to MDMB-CHMICA, a synthetic cannabinoid receptor agonist

@article{Meyyappan2017PoisoningDT,
  title={Poisoning due to MDMB-CHMICA, a synthetic cannabinoid receptor agonist},
  author={Chitra Meyyappan and Loretta T Ford and Allister Vale},
  journal={Clinical Toxicology},
  year={2017},
  volume={55},
  pages={151 - 152}
}
The journal has just published two articles on the features of MDMB-CHMICA poisoning, and all 16 cases reported were confirmed analytically.[1,2] In addition, there have been reports of two deaths.[3,4] Hill et al. [1] observed a reduced level of consciousness in four of seven patients, tonic–clonic convulsions in two, respiratory acidosis in three (and in all, three of those who had used MDMB-CHMICA alone), agitation in three, and a variable impact on the pulse rate (sinus tachycardia 5/7 and… 
6 Citations
Acute side effects after consumption of the new synthetic cannabinoids AB-CHMINACA and MDMB-CHMICA
TLDR
The valine derivative AB-CHMINACA and the tert-leucine derivative MDMB-CHMICA (“third generation of SCs”) seem to be associated with more severe clinical toxicity than was previously reported in patients exposed to earlier generation SCs such as JWH-018.
Human Toxicity Caused by Indole and Indazole Carboxylate Synthetic Cannabinoid Receptor Agonists: From Horizon Scanning to Notification.
TLDR
A toxicovigilance system for NPS is described that predicted the emergence of misuse of indole and indazole carboxylate SCRA, documented associated clinical harms, and notified relevant agencies.
Cannabinoids: from pot to lab
TLDR
Some of the novel aspects of cannabis and cannabinoids in relation to their legal situation, changes in their composition and forms of cannabis use, the concept of medical cannabis, and synthetic cannabinoids as new psychoactive substances (NPS) are reviewed.
The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogs.
TLDR
Five SCRA NPS evaluated in vivo using radio biotelemetry did not produce cannabimimetic effects in mice at doses up to 10 mg/kg and expansion of the pyrrolidine ring of 5F-PY-PICA to an azepane conferred the greatest hCB2 affinity and activity within the series.
The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogues
TLDR
5F-PYPICA and 5F-Y-PINACA did not produce cannabimimetic effects in mice at doses up to 10 mg/kg, and analogues intended to explore structure-activity relationships within this class of SCRAs were synthesized and characterized.

References

SHOWING 1-7 OF 7 REFERENCES
Four analytically confirmed cases of use of third-generation synthetic cannabinoid receptor agonists incorporating an adamantyl group
TLDR
The clinical course of four patients who were admitted to the West Midlands Poisons Unit, City Hospital, Birmingham, UK, from a nearby prison within a 6-h period and their urine was positive for the presence of a third generation synthetic cannabinoid receptor agonist incorporating an adamantyl group.
Fatal intoxication with synthetic cannabinoid MDMB-CHMICA.
Analysis and clinical findings of cases positive for the novel synthetic cannabinoid receptor agonist MDMB-CHMICA
TLDR
The clinical presentations observed were typical of synthetic cannabinoid receptor agonists and show the difficulties in identifying reactions potentially associated with drugs of this type, as well as the potential for harm associated with low concentrations of MDMB-CHMICA and the symptoms of toxicity being non-specific were highlighted.
Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study
TLDR
Analytically confirmed exposure to MDMB-CHMICA was associated with acidosis, reduced level of consciousness, mydriasis, heart rate disturbances and convulsions, and recovery occurred within 24 h in all cases except one male also exposed to methiopropamine.
Analysis of legal high materials by ultra-performance liquid chromatography with time of flight mass spectrometry as part of a toxicology vigilance system: what are the most popular novel psychoactive substances in the UK?
TLDR
Testing suspect materials using ultra-performance liquid chromatography with time of flight mass spectrometry has identified three common novel psychoactive substances in use in the UK, simplifying the development of a relevant novel psycho active substances screening service to the population.
Sudden Cardiac Death Following Use of the Synthetic Cannabinoid MDMB-CHMICA.
Analysis of legal high materials by UPLC-MS/TOF as part of a toxicology vigilance system. What are the most popular novel psychoactive substances in the UK
  • Ann Clin Biochem
  • 2016