Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis.

@article{Morimoto1996PointedAE,
  title={Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis.},
  author={Alyssa M. Morimoto and Katherine C. Jordan and Konrad Tietze and Jessica S Britton and Elizabeth M. O'Neill and Hannele Ruohola-Baker},
  journal={Development},
  year={1996},
  volume={122 12},
  pages={3745-54}
}
Spatially regulated activation of the Drosophila epidermal growth factor (EGF) receptor by its ligand, Gurken, is required for establishment of the dorsal/ventral axis of the oocyte and embryo. During mid-oogenesis, Gurken is concentrated at the dorsal-anterior of the oocyte and is thought to activate the EGF receptor pathway in adjacent follicle cells. In response to this signal, dorsal follicle cell fate is determined. These cells further differentiate into either appendage-producing or… CONTINUE READING

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