Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.

@article{Lal2015PointofcareEC,
  title={Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.},
  author={Ashutosh Lal and Lasandra Patterson and Alisa M Goldrich and Anne M Marsh},
  journal={Pediatric blood & cancer},
  year={2015},
  volume={62 5},
  pages={912-4}
}
Carbon monoxide (CO) production from heme catabolism is increased with hemolysis. A portable end-tidal CO (ETCO) monitor was used to analyze breath samples in 16 children with sickle cell anemia (SCA, 5-14 years). Median (range) ETCO for SCA was 4.35 ppm (1.8-9.7) versus 0.80 ppm (0.2-2.3) for controls (P < 0.001). ETCOc >2.1 ppm provided sensitivity and specificity of 93.8% (69.8-99.8%) for detecting SCA. ETCO correlated with reticulocytosis (P = 0.015) and bilirubin (P = 0.009), and was 32… CONTINUE READING