Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid.

@article{Kabanda2014PointofcareDA,
  title={Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid.},
  author={Taseera Kabanda and Mark J. Siedner and Jeffrey D. Klausner and Conrad K. Muzoora and David R Boulware},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2014},
  volume={58 1},
  pages={113-6}
}
The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R(2) = 0.7) and predicted 2- and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis. 
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