Corpus ID: 6371332

Point of View Research on Unstable Coronary Syndromes Unstable Angina A Classification

  title={Point of View Research on Unstable Coronary Syndromes Unstable Angina A Classification},
  author={E. Braunwald},
T he establishment of a prognosis and the approach to the treatment of many diseases is aided greatly by a logical classification. For example, classification of a wide variety of neoplasms by anatomic extent, microscopic appearance, and the presence of special markers now forms the basis for selecting appropriate therapy. In cardiology, the classification of patients with acute myocardial infarction and congestive heart failure has been of enormous value in following the progress and in… Expand


Pathogenetic classifications of unstable angina as a guideline to individual patient management and prognosis.
  • A. Maseri
  • Medicine
  • The American journal of medicine
  • 1986
The pathophysiologic classification proposed in this article considers both the severity of the underlying coronary fixed obstructions and the tendency for dynamic stenoses to develop and can be applied easily in clinical practice and may provide more rational groupings of patients for both management and prognosis assessment. Expand
A decision scheme for coronary angiography after acute myocardial infarction.
A modified decision scheme for coronary angiography was developed and then tested in a second population (n = 780), and this relatively simple scheme does not make general recommendations in the elderly, considers patients with in-hospital left ventricular failure or reducedLeft ventricular function or both, and approaches the problem of patients who do not perform an exercise test. Expand
Angiographic evolution of coronary artery morphology in unstable angina.
The eccentric lesion was seen in 71% of all lesions with progression to less than 100% occlusion in Group I, but it was not seen in any Group II vessel with progression. Expand
Insights into the pathogenesis of acute ischemic syndromes.
This review focuses on three areas of recent progress: the interaction between platelets, thrombosis, and blood rheology in experimental vessel wall injury, the relevance of these blood vessel interactions to the acute coronary syndromes in man, and the usefulness of antithrombotic therapy in reducing morbidity and mortality in man. Expand
Effects of thrombolytic therapy in unstable angina: clinical and angiographic results.
A high incidence of coronary thrombosis in patients with unstable angina is suggested and better risk stratification and placebo-controlled prospective studies are required to obtain information on the risk/benefit ratio of thrombolytic therapy in unstableAngina. Expand
“Preinfarctional” Angina: A Need for an Objective Definition and for a Controlled Clinical Trial of its Management
The question of whether preinfarctional angina (better called unstable angina) can be recognized and defined by objective criteria is addressed, and the need for a controlled clinical trial of saphenous vein grafting in the management of angina pectoris is considered. Expand
Unstable angina and progression of coronary atherosclerosis.
It is demonstrated by angiography that unstable angina is associated with progression in the extent and severity of coronary atherosclerosis. Expand
  • R. Vakil
  • Medicine
  • The American journal of cardiology
  • 1964
The prompt and adequate administration of anticoagulants appears desirable as a routine prophylactic measure against myocardial infarction in cases of the preinfarction syndrome, and the general impression afforded by the data favors a routine adoption of antICOagulant therapy as a safeguard against my cardiac infarctions in such cases. Expand
Clinical spectrum of “Unstable Angina”
In order to determine the natural evolution of different clinical types of “unstable angina”, 167 patients were included in a prospective study and mortality and incidence of acute myocardial infarction were determined. Expand
Unstable angina pectoris: National cooperative study group to compare surgical and medical therapy: II. In-Hospital experience and initial follow-up results in patients with one, two and three vessel disease
The results indicate that patients with unstable angina pectoris can be managed acutely with intensive medical therapy, including the administration of propranolol and long-acting nitrates in pharmacologic doses, with adequate control of pain in most patients and no increase in early mortality or myocardial infarction rates. Expand