Point mutations of mitochondrial genome in Parkinson's disease.

  title={Point mutations of mitochondrial genome in Parkinson's disease.},
  author={Shin-ichiro Ikebe and Masashi Tanaka and Tetsuro Ozawa},
  journal={Brain research. Molecular brain research},
  volume={28 2},
Oxidative stress and subsequent energy crisis have been proposed as the cause of nigral neuronal cell death in Parkinson's disease. We have reported defects in the mitochondrial respiratory chain and increased amount of deleted mitochondrial genome in the nigrostriatal system of patients with Parkinson's disease. Deletion in mitochondrial DNA could be ascribed to somatically acquired premature aging leading to cell death. To elucidate the contribution of maternally transmitted point mutations… CONTINUE READING


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