Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria.

@article{Happi2003PointMI,
  title={Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria.},
  author={T Christian Happi and Susan M. Thomas and Grace Olusola Gbotosho and Catherine Olufunke Falade and Dora Olufunmilola Akinboye and Lucia Gerena and Thomas Hudson and A. Sowunmi and Dennis E. Kyle and Wilbur K. Milhous and Dyann F Wirth and Ayoade M. J. Oduola},
  journal={Annals of tropical medicine and parasitology},
  year={2003},
  volume={97 5},
  pages={439-51}
}
Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with specific point mutations in the pfcrt and pfmdr-1 genes. In the present study, 30 children aged 1-12 years, who were all suffering from acute, uncomplicated, P. falciparum malaria in Ibadan, Nigeria, were evaluated to assess the association between these mutations and clinical outcome following treatment with CQ. The parasites, in blood samples collected pre-treatment and, in those who failed treatment, on the day… CONTINUE READING

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