Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III

@inproceedings{Iben2011PointMI,
  title={Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III},
  author={James R. Iben and Julie K. Mazeika and Sam Hasson and K Saiful Rijal and Aneeshkumar Gopalakrishnan Arimbasseri and Amy N. Russo and Richard J Maraia},
  booktitle={Nucleic acids research},
  year={2011}
}
RNA polymerase III recognizes and pauses at its terminator, an oligo(dT) tract in non-template DNA, terminates 3' oligo(rU) synthesis within this sequence, and releases the RNA. The pol III subunit Rpc11p (C11) mediates RNA 3'-5' cleavage in the catalytic center of pol III during pausing. The amino and carboxyl regions of C11 are homologous to domains of the pol II subunit Rpb9p, and the pol II elongation and RNA cleavage factor, TFIIS, respectively. We isolated C11 mutants from… CONTINUE READING

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