Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi.

@article{Carr1994PointMI,
  title={Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi.},
  author={Jill M Carr and Rona M. MacKie},
  journal={The British journal of dermatology},
  year={1994},
  volume={131 1},
  pages={72-7}
}
DNA from formalin-fixed and paraffin-processed samples from 100 melanocytic lesions (39 malignant melanomas, 18 cases of dysplastic naevi, and 43 congenital naevi) was extracted, and the sequences around codons 12/13 and 61 of the N-ras oncogene were amplified using the polymerase chain reaction. The amplified product was then analysed both by dot-blotting and by direct sequencing for point mutations. By the dot-blotting technique, mutations were seen in 18 of 100 lesions. These were in one of… CONTINUE READING

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