Point mutations in the DNA binding domain of p53 contribute to glioma progression and poor prognosis

@article{Sarma2017PointMI,
  title={Point mutations in the DNA binding domain of p53 contribute to glioma progression and poor prognosis},
  author={Pranjal Sarma and Dibyendu Dutta and Zeenat Mirza and Kandarpa Kr. Saikia and Bikash Baishya},
  journal={Molecular Biology},
  year={2017},
  volume={51},
  pages={293-299}
}
TP53 mutations play a significant role in glioma tumorigenesis. When located in in the DNA binding domain, these mutations can perturb p53 protein conformation and its function, often culminating in altered downstream signaling. Here we describe prevalent pattern of TP53 point mutations in a cohort of 40 glioma patients and show their relevance to… CONTINUE READING