Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin.

@article{Wang1998PointMI,
  title={Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin.},
  author={S. Y. Wang and G. K. Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={2653-8}
}
Batrachotoxin (BTX) is a steroidal alkaloid that causes Na+ channels to open persistently. This toxin has been used widely as a tool for studying Na+ channel gating processes and for estimating Na+ channel density. In this report we used point mutations to identify critical residues involved in BTX binding and to examine if such mutations affect channel gating. We show that a single asparagine --> lysine substitution of the rat muscle Na+ channel alpha-subunit, mu1-N434K, renders the channel… CONTINUE READING

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4 Excerpts

Wang and Wang Proc

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