Point mutations in Moloney murine leukemia virus envelope protein: effects on infectivity, virion association, and superinfection resistance.


Retroviral envelope proteins are synthesized in the infected cell and targetted to the assembling virion; during infection, they mediate receptor binding and fusion of the virion and cell membranes. We have generated a series of mutants of the Moloney murine leukemia virus (M-MuLV) with alterations in the TM protein, p15E, and determined whether the mutants… (More)


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