Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters.

@article{Oelmann2001PointMI,
  title={Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters.},
  author={Stefan Oelmann and Pamela Stanley and Rita Gerardy-Schahn},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 28},
  pages={
          26291-300
        }
}
Nucleotide-sugar transporters (NSTs) are critical components of glycosylation pathways in eukaryotes. The identification of structural elements that are involved in NST functions provides an important task. Chinese hamster ovary glycosylation mutants defective in nucleotide-sugar transport provide access to inactive transporters that can define such structure/function relationships. In this study, we have cloned the hamster UDP-galactose transporter (UGT) and identified defects in UGT gene… CONTINUE READING

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