Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature.

@article{Stoppani2011PointMC,
  title={Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature.},
  author={Elena Stoppani and Stefania Rossi and Elisabetta Meacci and Fabio Penna and Paola Costelli and Arianna Bellucci and Fiorella Faggi and Daniele Maiolo and Eugenio Monti and Alessandro Fanzani},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1812 4},
  pages={468-79}
}
Unbalanced levels of caveolin-3 (Cav3) are involved in muscular disorders. In the present study we show that differentiation of immortalized myoblasts is affected by either lack or overexpression of Cav3. Nevertheless, depletion of Cav3 induced by delivery of the dominant-negative Cav3 (P104L) form elicited a more severe phenotype, characterized by the simultaneous attenuation of the Akt and p38 signalling networks, leading to an immature cell and molecular signature. Accordingly… CONTINUE READING

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