Point-counterpoint of sphingosine 1-phosphate metabolism.

  title={Point-counterpoint of sphingosine 1-phosphate metabolism.},
  author={Julie D Saba and Timothy Hla},
  journal={Circulation research},
  volume={94 6},
Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is now recognized as a potent modulator of cell regulation. In vertebrates, S1P interacts with cell surface G protein-coupled receptors of the EDG family and induces profound effects in a variety of organ systems. Indeed, an S1P receptor agonist is undergoing clinical trials to combat immune-mediated transplant rejection. Recent information on S1P receptor biology suggests potential utility in the control of… CONTINUE READING

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