Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses

@article{Minichiello1998PointMI,
  title={Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses},
  author={Liliana Minichiello and Franca Casagranda and Rosa Soler Tatche and Cheryl L Stucky and Antonio Postigo and Gary R Lewin and Alun M Davies and Ruediger Klein},
  journal={Neuron},
  year={1998},
  volume={21},
  pages={335-345}
}
Neurotrophins are a family of soluble ligands that promote the survival and differentiation of peripheral and central neurons and regulate synaptic function. The two neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), bind and activate a single high-affinity receptor, TrkB. Experiments in cell culture have revealed that an intact Shc adaptor binding site on TrkB and subsequent activation of the Ras/MAPK pathway are important for neuronal survival and neurite… CONTINUE READING

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