Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.

  title={Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.},
  author={Anne Feyler and Anu Voho and Christine Bouchardy and Katja Kuokkanen and Pierre Dayer and Ari P Hirvonen and Simone Benhamou},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={11 12},
Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking. This enzyme is involved in the activation of an intermediate metabolite of benzo(a)pyrene to the highly reactive benzo(a)pyrene diol epoxide. A (-463)G --> A polymorphism in the promoter region of the MPO gene has been identified. The A allele is associated with a decreased transcriptional activity attributable to the disruption of a SP1-binding site… CONTINUE READING


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