Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.
@article{Esler2010PointCA, title={Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.}, author={Murray Esler and Elisabeth A. Lambert and Markus P. Schlaich}, journal={Journal of applied physiology}, year={2010}, volume={109 6}, pages={ 1996-8; discussion 2016 } }
For the past three decades, the renin-angiotensin system has been the major focus in high blood pressure research. The proven value of antihypertensive drugs that block this system has deflected research from other blood pressure-raising systems, including the sympathetic nervous system. Despite
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Last Word on Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension
- Medicine
- 2010
to the editor: I thank my friends, colleagues, and opponents for their thoughtful submissions (see Ref. [1][1]), which capture the diversity of views concerning the pathophysiological mechanisms of…
Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.
- MedicineJournal of applied physiology
- 2010
The dominant mechanism responsible for hypertension calls to mind the famous poem, “The Blind Men and the Elephant,” by John Godfrey Saxe based on an ancient fable from India, which described the elephant based on their specific encounter.
The sympathetic nervous system and blood pressure in humans: implications for hypertension
- Medicine, BiologyJournal of Human Hypertension
- 2012
A perspective on the actions and interactions of angiotensin II, inflammation and vascular dysfunction/brain hypoperfusion in the pathogenesis and progression of neurogenic hypertension is provided.
Physiology: hemodynamics, endothelial function, renin-angiotensin-aldosterone system, sympathetic nervous system.
- Biology, MedicineJournal of the American Society of Hypertension : JASH
- 2014
Pathophysiology of Renal Sympathetic Denervation (RSDN)
- Biology, Medicine
- 2016
Activation of the sympathetic nervous system (SNS) has been identified as a key pathophysiological feature involved in the initiation, progression but also prognosis of most cardiometabolic disorders…
Renal denervation for resistant hypertension.
- Medicine, BiologyRevista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
- 2015
The Causal Role of Chronic Mental Stress in the Pathogenesis of Essential Hypertension
- Medicine
- 2011
The idea that essential hypertension may arise through psychosomatic mechanisms is an old one and one finds an unusual frequency of those who as directors of big enterprises had a great deal of responsibility and demanding jobs, and who, after a long period of mental overwork, became nervous.
The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation
- Medicine, BiologyExperimental physiology
- 2015
The role of renal nerves is described as the key carrier of signals from the kidneys to the CNS and vice versa; the brain and kidneys communicate through this carrier to maintain homeostasis in the body.
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system
- Medicine, Biology
- 2014
It is reported that urinary angiotensinogen levels are significantly greater in hypertensive patients not treated with RAS blockers compared with normotensive subjects, and an activated intrarenal RAS is correlated with high blood pressure in humans.
Central regulation of sympathetic nerve activity by adipokines and insulin
- Biology, Medicine
- 2017
Hormones that circulate in the blood and cross the blood brain barrier are thought to activate specific regions, which play important roles in energy homeostasis and cardiovascular regulation.
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