Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.

@article{Esler2010PointCA,
  title={Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.},
  author={Murray Esler and Elisabeth A. Lambert and Markus P. Schlaich},
  journal={Journal of applied physiology},
  year={2010},
  volume={109 6},
  pages={
          1996-8; discussion 2016
        }
}
For the past three decades, the renin-angiotensin system has been the major focus in high blood pressure research. The proven value of antihypertensive drugs that block this system has deflected research from other blood pressure-raising systems, including the sympathetic nervous system. Despite 

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Last Word on Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension
to the editor: I thank my friends, colleagues, and opponents for their thoughtful submissions (see Ref. [1][1]), which capture the diversity of views concerning the pathophysiological mechanisms of
Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.
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The dominant mechanism responsible for hypertension calls to mind the famous poem, “The Blind Men and the Elephant,” by John Godfrey Saxe based on an ancient fable from India, which described the elephant based on their specific encounter.
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A perspective on the actions and interactions of angiotensin II, inflammation and vascular dysfunction/brain hypoperfusion in the pathogenesis and progression of neurogenic hypertension is provided.
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Activation of the sympathetic nervous system (SNS) has been identified as a key pathophysiological feature involved in the initiation, progression but also prognosis of most cardiometabolic disorders
Renal denervation for resistant hypertension.
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The Causal Role of Chronic Mental Stress in the Pathogenesis of Essential Hypertension
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Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system
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It is reported that urinary angiotensinogen levels are significantly greater in hypertensive patients not treated with RAS blockers compared with normotensive subjects, and an activated intrarenal RAS is correlated with high blood pressure in humans.
Central regulation of sympathetic nerve activity by adipokines and insulin
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Hormones that circulate in the blood and cross the blood brain barrier are thought to activate specific regions, which play important roles in energy homeostasis and cardiovascular regulation.
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References

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The renal sympathetic nerves have been identified as a major contributor to the complex pathophysiology of hypertension in both experimental models and in humans and may be modulated by afferent signaling from renal sensory nerves.
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TLDR
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Sympathetic Augmentation in Hypertension: Role of Nerve Firing, Norepinephrine Reuptake, and Angiotensin Neuromodulation
TLDR
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TLDR
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