Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma

  title={Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma},
  author={Masayuki Tsuneki and Manabu Yamazaki and Satoshi Maruyama and Jun Cheng and Takashi Saku},
  journal={Laboratory Investigation},
Podoplanin (PDPN), one of the representative mucin-like type-I transmembrane glycoproteins specific to lymphatic endothelial cells, is expressed in various cancers including squamous cell carcinoma (SCC). On the basis of our previous studies, we have developed the hypothesis that PDPN functions in association with the extracellular matrix (ECM) from the cell surface side. The aim of this study was to elucidate the molecular role of PDPN in terms of cell adhesion, proliferation, and migration in… CONTINUE READING


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