Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

Abstract

To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN). PDPN is expressed by lymphatic endothelial and fibroblastic reticular cells and promotes blood-lymph separation during development by activating the C-type lectin receptor… (More)
DOI: 10.1016/j.immuni.2012.05.022

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Cite this paper

@inproceedings{Acton2012PodoplaninRichSN, title={Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2}, author={Sophie E. Acton and Jillian L. Astarita and Deepali Malhotra and Veronika Lukacs-Kornek and Bettina Franz and Paul R. Hess and Zolt{\'a}n Jakus and Michael P Kuligowski and Anne L. Fletcher and Kutlu G. Elpek and Ang{\'e}lique Bellemare-Pelletier and Lindsay Sceats and Erika D. Reynoso and Santiago F. Gonzalez and Daniel B. Graham and Jonathan E Chang and Anneli Peters and Matthew C. Woodruff and Young-A. Kim and Wojciech Swat and Takashi Morita and Vijay K Kuchroo and Michael C. Carroll and Mark L. Kahn and Kai W. Wucherpfennig and Shannon J. Turley}, booktitle={Immunity}, year={2012} }