Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin.

@article{Cueni2010PodoplaninFcRL,
  title={Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin.},
  author={L. Cueni and Lu Chen and Hui Bin Zhang and Daniela Marino and R. Huggenberger and A. Alitalo and R. Bianchi and M. Detmar},
  journal={Blood},
  year={2010},
  volume={116 20},
  pages={
          4376-84
        }
}
Podoplanin is a small transmembrane protein required for development and function of the lymphatic vascular system. To investigate the effects of interfering with its function, we produced an Fc fusion protein of its ectodomain. We found that podoplanin-Fc inhibited several functions of cultured lymphatic endothelial cells and also specifically suppressed lymphatic vessel growth, but not blood vessel growth, in mouse embryoid bodies in vitro and in mouse corneas in vivo. Using a keratin 14… Expand
Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity*
The physiological and pathophysiological roles of platelet CLEC-2.
Podoplanin in Inflammation and Cancer
CLEC-2 is required for development and maintenance of lymph nodes.
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
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