Podophyllotoxins: Current Status and Recent Developments

@article{Damayanthi1998PodophyllotoxinsCS,
  title={Podophyllotoxins: Current Status and Recent Developments},
  author={Yalamati Damayanthi and J. William Lown,},
  journal={Current Medicinal Chemistry},
  year={1998}
}
Podophyllotoxin is a natural product isolated from Podophyllum peltatum and Podophyllum emodi and has long been known to possess medicinal properties. Etoposide (VP-16), a podophyllotoxin derivative, is currently in clinical use in the treatment of many cancers, particularly small cell lung carcinoma and testicular cancer. This compound arrests cell growth by inhibiting DNA tope­ isomerase II, which causes double strand breaks in DNA. VP-16 does not inhibit tubulin polymerization, however… 
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