Podophyllotoxin and Rutin Modulates Ionizing Radiation-Induced Oxidative Stress and Apoptotic Cell Death in Mice Bone Marrow and Spleen

@inproceedings{Singh2017PodophyllotoxinAR,
  title={Podophyllotoxin and Rutin Modulates Ionizing Radiation-Induced Oxidative Stress and Apoptotic Cell Death in Mice Bone Marrow and Spleen},
  author={Abhinav Singh and M. H. Yashavarddhan and Bhargab Kalita and Rajiv Ranjan and Sania Bajaj and Hridayesh Prakash and Manju Lata Gupta},
  booktitle={Front. Immunol.},
  year={2017}
}
The present study is aimed to investigate the radioprotective efficacy of G-003M (combination of podophyllotoxin and rutin) against gamma radiation-induced oxidative stress and subsequent cell death in mice bone marrow and spleen. Prophylactic administration of G-003M (-1 h) rendered more than 85% survival in mice exposed to 9 Gy (lethal dose) with dose reduction factor of 1.26. G-003M pretreated mice demonstrated significantly reduced level of reactive oxygen species, membrane lipid… CONTINUE READING
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