Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.

  title={Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.},
  author={Marina Gordaliza and Pablo A Garc{\'i}a and Jos{\'e} Mar{\'i}a Miguel del Corral and Mar{\'i}a {\'A}ngeles Castro and Ma Antonia G{\'o}mez-Zurita},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={44 4},
Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the microM level. Distribution, biosynthesis, production, biotechnology, applications and… CONTINUE READING
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