Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes

@article{Sayyed2009PodocytesPH,
  title={Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes},
  author={Sufyan G. Sayyed and Holger H{\"a}gele and Onkar P Kulkarni and K. Endlich and Stephan Segerer and Dirk Eulberg and Sven Klussmann and H J Anders},
  journal={Diabetologia},
  year={2009},
  volume={52},
  pages={2445-2454}
}
Chemokine (C-X-C motif) ligand 12 (CXCL12) (also known as stromal cell-derived factor-1 [SDF-1]-alpha) is a homeostatic chemokine with multiple roles in cell homing, tumour metastasis, angiogenesis and tissue regeneration after acute injuries. However, its role in chronic diseases remains poorly defined, e.g. in chronic glomerular diseases like diabetic glomerulosclerosis. We hypothesised that CXCL12 may have a functional role during the evolution of diabetic glomerulosclerosis, either by… CONTINUE READING

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