Podocytes Regulate Neutrophil Recruitment by Glomerular Endothelial Cells via IL-6–Mediated Crosstalk

@inproceedings{Kuravi2014PodocytesRN,
  title={Podocytes Regulate Neutrophil Recruitment by Glomerular Endothelial Cells via IL-6–Mediated Crosstalk},
  author={Sahithi Jyothsna Kuravi and Helen M McGettrick and Simon C. Satchell and Moin Saleem and Lorraine Harper and Julie Marie Williams and G Ed Rainger and Caroline O. S. Savage},
  booktitle={Journal of immunology},
  year={2014}
}
Stromal cells actively modulate the inflammatory process, in part by influencing the ability of neighboring endothelial cells to support the recruitment of circulating leukocytes. We hypothesized that podocytes influence the ability of glomerular endothelial cells (GEnCs) to recruit neutrophils during inflammation. To address this, human podocytes and human GEnCs were cultured on opposite sides of porous inserts and then treated with or without increasing concentrations of TNF-α prior to… CONTINUE READING

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