Podocyte damage damages podocytes: autonomous vicious cycle that drives local spread of glomerular sclerosis.

Abstract

PURPOSE OF REVIEW For some time, the so-called vicious cycle has been believed to underlie progression of glomerular sclerosis. This mechanism describes a circumstance when loss of some glomeruli imposes injurious stress on the remnant glomeruli. Evidence from recent genetic approaches, however, has prompted revision of this classical view and now points… (More)

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