Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced

@inproceedings{Lasagni2015PodocyteRD,
  title={Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced},
  author={Laura Lasagni and Maria Lucia Angelotti and Elisa Ronconi and Duccio Lombardi and Sara Di Nardi and Anna Julie Peired and Francesca Becherucci and Benedetta Mazzinghi and Alessandro Sisti and Simone Romoli and Alexa Burger and Beat W Sch{\"a}fer and Annamaria Buccoliero and Elena Lazzeri and Paola Romagnani},
  booktitle={Stem cell reports},
  year={2015}
}
Podocyte loss is a general mechanism of glomerular dysfunction that initiates and drives the progression of chronic kidney disease, which affects 10% of the world population. Here, we evaluate whether the regenerative response to podocyte injury influences chronic kidney disease outcome. In models of focal segmental glomerulosclerosis performed in inducible transgenic mice where podocytes are tagged, remission or progression of disease was determined by the amount of regenerated podocytes. When… CONTINUE READING

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