Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization.

@article{Forst2016PodocytePP,
  title={Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization.},
  author={Anna-Lena Forst and Vlad Sorin Olteanu and G. S. Mollet and Tanja Tamara Wlodkowski and Franz S. Schaefer and Alexander Dietrich and Jochen Reiser and Thomas Gudermann and Michael Mederos y Schnitzler and Ursula Storch},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 3},
  pages={848-62}
}
Podocytes are specialized, highly differentiated epithelial cells in the kidney glomerulus that are exposed to glomerular capillary pressure and possible increases in mechanical load. The proteins sensing mechanical forces in podocytes are unconfirmed, but the classic transient receptor potential channel 6 (TRPC6) interacting with the MEC-2 homolog podocin may form a mechanosensitive ion channel complex in podocytes. Here, we observed that podocytes respond to mechanical stimulation with… CONTINUE READING