Pneumolysin localizes to the cell wall of Streptococcus pneumoniae.

  title={Pneumolysin localizes to the cell wall of Streptococcus pneumoniae.},
  author={Katherine E. Price and Andrew Camilli},
  journal={Journal of bacteriology},
  volume={191 7},
Streptococcus pneumoniae is the causative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis. Pneumolysin (Ply), a member of the cholesterol-dependent cytolytic pore-forming toxins, is produced by virtually all clinical isolates of S. pneumoniae, and strains in which the Ply gene has been deleted are severely attenuated in mouse models of infection. In contrast to all other members of the cholesterol-dependent cytolysin family, Ply lacks a signal peptide… CONTINUE READING
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