Pneumolysin causes neuronal cell death through mitochondrial damage.

  title={Pneumolysin causes neuronal cell death through mitochondrial damage.},
  author={Johann Sebastian Braun and Olaf Hoffmann and Miriam Schickhaus and Dorette Freyer and Emilie Dagand and Daniela Bermpohl and Tim J Mitchell and Ingo Bechmann and Joerg R. Weber},
  journal={Infection and immunity},
  volume={75 9},
Bacterial toxins such as pneumolysin are key mediators of cytotoxicity in infections. Pneumolysin is a pore-forming toxin released by Streptococcus pneumoniae, the major cause of bacterial meningitis. We found that pneumolysin is the pneumococcal factor that accounts for the cell death pathways induced by live bacteria in primary neurons. The pore-forming activity of pneumolysin is essential for the induction of mitochondrial damage and apoptosis. Pneumolysin colocalized with mitochondrial… CONTINUE READING