Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone.

@article{Sul2001PneumocystisCF,
  title={Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone.},
  author={D Sul and Edna S. Kaneshiro},
  journal={The Journal of eukaryotic microbiology},
  year={2001},
  volume={48 2},
  pages={182-7}
}
Ubiquinone, coenzyme Q, plays a pivotal role in electron transport and is a target for chemotherapy against a number of eukaryotic infectious agents, including Pneumocystis carinii. Coenzyme Q10 was previously identified as the major ubiquinone homolog in P. carinii isolated and purified from rat lungs; CoQ9 was also present. In contrast, CoQ9 and CoQ8 (but not CoQ10) were detected in the lungs of uninfected rat controls. These observations suggested that the pathogen synthesizes CoQ10, and… CONTINUE READING