Pneumocystis‐mediated IL‐8 release by macrophages requires coexpression of mannose receptors and TLR2

@article{Tachado2007PneumocystismediatedIR,
  title={Pneumocystis‐mediated IL‐8 release by macrophages requires coexpression of mannose receptors and TLR2},
  author={Souvenir D. Tachado and Jianmin Zhang and Jinping Zhu and Naimish R. Patel and Melanie T. Cushion and Henry Koziel},
  journal={Journal of Leukocyte Biology},
  year={2007},
  volume={81}
}
Interaction with the unique fungus Pneumocystis (Pc) promotes IL‐8 release by human alveolar macrophages (AM), although the receptor(s) mediating IL‐8 release have not been identified. TLR2 recognizes fungal components and mediates release of host defense cytokines and chemokines, although whether TLR2 mediates signaling in response to Pc is not known. In the current study, Pc induced IL‐8 release by human AM, and AM pretreatment with anti‐TLR2 neutralizing antibody reduced IL‐8 release… Expand
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