Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia

  title={Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia},
  author={Joel B. Cochran and Valerie M. Panzarino and Lanne Y. Maes and Frederick W. Tecklenburg},
  journal={Pediatric Nephrology},
The hemolytic uremic syndrome (HUS) is most commonly associated with Escherichia coli, but has been associated with other infections such as Streptococcus pneumoniae. Pneumococcus-induced HUS carries an increased risk of mortality and renal morbidity compared with E. coli-induced HUS. The pneumococcal organism produces an enzyme, which can expose an antigen (T-antigen) present on erythrocytes, platelets, and glomeruli. Antibodies to the T-antigen, normally found in human serum, bind the exposed… CONTINUE READING